Extreme Sedation and Yawning. Despite if I smoke, vaporize or take in 4-AcO-DMT, dependant upon dosage degree I undergo extreme yawning and feel pretty sedated and sleepy. The most I’ve ever taken at once time was 280mg of 4-AcO-DMT And that i yawned hard for about an hour. Abnormal yawning - This influence seems to be uniquely pronounced amon